Nanotechnology meets Biology and DNA finds its groove

ource:www.eurekalert.org

The object of fascination for most is the DNA molecule. But in solution, DNA, the genetic material that hold the detailed instructions for virtually all life, is a twisted knot, looking more like a battered ball of yarn than the famous double helix. To study it, scientists generally are forced to work with collections of molecules floating in solution, and there is no easy way to precisely single out individual molecules for study.

Now, however, scientists have developed a quick, inexpensive and efficient method to extract single DNA molecules and position them in nanoscale troughs or “slits,” where they can be easily analyzed and sequenced.

The technique, which according to its developers is simple and scalable, could lead to faster and vastly more efficient sequencing technology in the lab, and may one day help underpin the ability of clinicians to obtain customized DNA profiles of patients. [Read the full article]